Figure 1. Demyelinating Phenotypes of the First Attack and Subsequent Relapses.

A total of 464 demyelinating events were reported in 102 patients presenting with myelin oligodendrocyte glycoprotein antibody–associated relapsing demyelination syndrome. Receiver operating characteristic analysis identified the age of 9 years to be the best cutoff age associated with phenotype change. Clinical events in patients 9 years or younger were more likely to affect the brain, whereas events in patients older than 9 years were more likely to affect the optic nerve (P < .001). Brain magnetic resonance imaging abnormalities were also more common in the younger group (P < .001). There was no sex predisposition of differences (female to male ratio in patients ≤9 vs >9 years old was 1.0:1.64 vs 1.0:1.6, P > .99).