Figure 3. Logistic Regression Model of the Apheresis Treatment Response.

This figure presents estimates on functional response to apheresis therapy. Estimates were obtained by multivariate logistic regression using Firth correction. The estimated log odds ratio of relevant covariates, including penalized likelihood profiles-based 95% confidence intervals, are given per patient experience of moderate/marked functional improvement after apheresis. Covariates with a negative log odds ratio predict no response, while covariates with a positive log odds ratio predict therapy success. Estimates are significant when the 95% CI bars do not cross the log odd ratio 0. Multivariate adjustment included immunopattern; neurological system, brainstem, or cognitive involvement; therapy with immunoadsorption, disease duration, and apheresis treatment delay.