Table 2. Association of Total PML Lesion Volume With Qualitative and Quantitative JCV PCR Results in CSF and Clinical Findings.
| Association | Total PML Lesion Volume, Median (IQR), mL | P Value |
|---|---|---|
| Qualitative JCV PCR | ||
| JCV positive (n = 57) | 22.9 (9.2-60.4) | .008a |
| JCV negative (n = 9) | 6.7 (4.9-14.7) | |
| Presence of PML symptoms, volume, mL | ||
| Present (n = 42) | 28.9 (10.1-60.6) | .005a |
| Not present (n = 14) | 9.2 (3.8-18.3) | |
| Lesion dissemination | ||
| Unilobar (n = 16) | 8.9 (4.6-19.5) | .001b |
| Multilobar (n = 8) | 14.8 (5.3-22.5) | |
| Widespread (n = 32) | 45.9 (16.3-63.4) |
Abbreviations: CSF, cerebrospinal fluid; IQR, interquartile range; JCV, JC virus; PCR, polymerase chain reaction, PML, progressive multifocal leukoencephalopathy.
a
Calculated by Mann-Whitney U test.
b
Calculated by Kruskal-Wallis test.