Table 3.

Generalized estimating equations with first order autoregressive correlation matrix comparing Hospital Anxiety and Depression Scale anxiety and depression and Impact of Event Scale scores over time, according to patient or spouse condition, gender and age

Parameters	Anxiety	Depression	PTSD
	Coefficient ± SD [95%CI]; p value	Coefficient ± SD [95%CI]; p value	Coefficient ± SD [95%CI]; p value
Female versus male	1.00 ± 0.46, [0.09 - 1.91]; 0.032	0.96 ± 0.45, [ 0.07 - 1.85]; 0.034	-0.08 ± 0.11, [ -0.29 - 0.13]; 0.472
Spouse versus patient	0.77 ± 0.46, [- 0.14 - 1.68]; 0.098	-0.04 ± 0.45, [-0.93 - 0.85]; 0.930	-0.37 ± 0.12, [-0.60 - -0.14]; 0.001
Age (per unit increase)	- 0.05 ± 0.01, [-0.08 - -0.03]; < 0.001	-0.02 ± 0.01, [-0.05 - 0.00]; 0.079	-0.04 ± 0.00, [ -0.04 - -0.03]; < 0.001
30-days versus baseline	-4.23 ± 0.32, [-4.86 - -3.61]; < 0.001	-1.44 ± 0.32, [ -2.07 - -0.80]; 0.001	-
90-days versus baseline*	-5.05 ± 0.37, [-5.76 - -4.33]; < 0.001	-0.67 ± 0.27, [ -1.20 - -0.14]; 0.013	-1.66 ± 0.19, [ -1.88 - -1.45]; < 0.001

PTSD - posttraumatic stress disorder; SD - standard deviation; 95%CI - 95% confidence interval.

^*For posttraumatic stress disorder, the reference was the assessment at 30 days.