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. Author manuscript; available in PMC: 2018 Nov 30.
Published in final edited form as: Thromb Haemost. 2017 Nov 30;117(11):2063–2078. doi: 10.1160/TH17-01-0067

Figure 6. Blockage of extracellular CyPA through 8H7-mAb does not affect hemostasis.

Figure 6

(A/B) 8H7-mAb treated mice did not exhibita prolonged tail bleeding time (A). After tail bleeding time the blood was collected and the number of platelets (B) and leukocytes (C) were estimated for both groups. (D) An in vivo treatment with 8H7-mAb did not change the surface expression of CD42b, CD29, CD41, CD49b, GPVI or the active form of αIIbβ3 on platelets compared to IgG control treated mice. (F/G) Every dot shows the response of one donor for the prothrombin time (E) and the activated partial thromboplastin time (F) (n=8). (G) PFA-100 measurement was performed with human blood. With the cartilages P2Y, Collagen/Epinephrine and Collage/ADP no difference could be detected.