Table 1. Baseline Characteristics of Eligible Patientsa.
| Characteristic | No. (%) | |
|---|---|---|
| NACT Plus RHT (n = 162) |
NACT Alone (n = 167) |
|
| Age, y | ||
| 18-40 | 44 (27.2) | 44 (26.3) |
| 41-70 | 118 (72.8) | 123 (73.7) |
| Median (range) | 51.0 (18.0-70.0) | 52.0 (19.0-70.0) |
| Sex | ||
| Male | 91 (56.2) | 91 (54.5) |
| Female | 71 (43.8) | 76 (45.5) |
| WHO performance status | ||
| 0 | 106 (65.4) | 112 (67.1) |
| 1 | 48 (29.6) | 48 (28.7) |
| 2 | 8 (4.9) | 7 (4.2) |
| Site of tumor | ||
| Nonextremityb | 93 (57.4) | 93 (55.7) |
| Extremity | 69 (42.6) | 74 (44.3) |
| Presentation of tumor | ||
| Primary | 75 (46.3) | 82 (49.1) |
| Recurrent | 19 (11.7) | 18 (10.8) |
| Prior surgery | 68 (42.0) | 67 (40.1) |
| Size of tumor, cm | ||
| 5.0-12.0 | 93 (57.4) | 106 (63.5) |
| >12.0 | 69 (42.6) | 61 (36.5) |
| Median (range) | 11.0 (5.0-36.0) | 11.0 (5.0-40.0) |
| Histologic grade | ||
| G2 | 79 (48.8) | 74 (44.3) |
| G3 | 83 (51.2) | 93 (55.7) |
| Histologic type | ||
| Liposarcoma | 30 (18.5) | 30 (18.0) |
| Leiomyosarcoma | 25 (15.4) | 27 (16.2) |
| Synovial sarcoma | 24 (14.8) | 19 (11.4) |
| Sarcoma NOS | 33 (20.4) | 35 (21.0) |
| Other sarcomac | 37 (22.8) | 39 (23.4) |
| Not soft-tissue sarcomad | 2 (1.2) | 4 (2.4) |
| Unreviewed sarcomae | 11 (6.8) | 13 (7.8) |
Abbreviations: NACT, neoadjuvant chemotherapy consisting of doxorubicin, ifosfamide, and etoposide; NOS, not otherwise specified; RHT, regional hyperthermia; WHO, World Health Organization.
Percentages may not sum to 100 because of rounding.
Nonextremity includes retroperitoneal-visceral tumors and tumors localized in the pelvis (81%), trunk (18%), and head and neck (1%).
Angiosarcoma, rhabdomyosarcoma, fibrosarcoma, myxofibrosarcoma, nerve sheath tumor, gastrointestinal tumor, epitheloid sarcoma, alveolar soft-part sarcoma, extraskeletal myxoid chondrosarcoma, myogenic not otherwise specified, haemangiopericytoma, malignant solitary fibrous tumor, extraskeletal Ewings sarcoma, myofibrosarcoma.
Anaplastic large-cell lymphoma, solid pseudopapillary neoplasm of the pancreas, pleomorphic T-cell lymphoma, atypical Burkitt lymphoma, giant-cell tumor of tendon sheath, chondrosarcoma (not mesenchymal).
Unreviewed means that external pathological review was not performed.