Table 2. Untimely First-line Benzodiazepine Treatment and Death, Adjusted for Confoundersa.
| Variable | Outcome Proportion, No. (%) (N = 218) | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| Received Untimely Treatment, No. (%) | P Value | AOR (95% CI) | P Value | ||
| Death | 7 (3.2) | 7 (100) | .98 | 11.0 (1.43 to ∞) | .02 |
| Structural cause | 62 (28.4) | 38 (61.3) | .35 | 0.1 (0 to 0.80) | .03 |
| Febrile RCSE | 45 (20.6) | 39 (86.7) | .001 | 0.05 (0 to 0.45) | .006 |
| Older than the median age of 4 y | 109 (50.0) | 69 (63.3) | .48 | 0.2 (0.02 to 1.61) | .16 |
| No previous neurology history | 78 (35.8) | 53 (67.9) | .77 | 11.3 (1.52 to 145.02) | .02 |
Abbreviations: AOR, adjusted odds ratio; RCSE, refractory convulsive status epilepticus.
a
The results of AORs for multivariate analysis using an exact logistic regression model, with untimely first-line benzodiazepine treatment (≥10 minutes after seizure onset) as the predictor and death as the primary outcome, adjusted for structural cause, febrile RCSE, age, and no neurological history. The main finding is that, after controlling for structural etiology, febrile RCSE, age, and no neurological history, we found that the AOR of death was 11 for patients with untimely first-line benzodiazepine treatment compared with patients with first-line benzodiazepine treatment in less than 10 minutes after seizure onset.