Figure. Differentiation Syndrome Review Committee Amended Protocol for Isocitrate Dehydrogenase Differentiation Syndrome (IDH-DS) Diagnosis and Management.

DIC indicates disseminated intravascular coagulation; WBC, white blood cells.

^aTypical onset is between 7 to 10 days and 5 months from start of enasidenib treatment or reinitiation of enasidenib after prolonged treatment interruption.

^bOwing to the long half-life of enasidenib, treatment may not immediately reverse symptoms of IDH-DS.