Table. Plasma Levels of Neurofilament Light and Tau Over Time, Stratified by Study.
| Time After Surgical Incision, h | CAPACITY Study | ARCADIAN Study | Combined Mean (SD), pg/mL | P Valuea | ||
|---|---|---|---|---|---|---|
| Mean (SD), pg/mL | Patients, No. (%) (n = 13) | Mean (SD), pg/mL | Patients, No. (%) (n = 17) | |||
| Neurofilament Light | ||||||
| 0 (baseline) | 11.7 (6.0) | 13 (100) | 30.4 (23.9) | 17 (100) | 22.3 (20.4) | .01 |
| 0.5 | NAb | NA | 29.5 (23.5) | 16 (94) | NA | NA |
| 6 | 17.2 (8.2) | 12 (92) | 35.6 (27.6) | 16 (94) | 27.7 (23.2) | .03 |
| 24 | 16.7 (5.1) | 13 (100) | 44.0 (25.9) | 16 (94) | 31.8 (23.7) | <.001 |
| 48 | 15.5 (4.1) | 12 (92) | 51.9 (30.1) | 14 (82) | 35.1 (28.7) | <.001 |
| Tau | ||||||
| 0 (baseline) | 2.6 (1.5) | 13 (100) | 3.4 (1.1) | 17 (100) | 3.1 (1.3) | .10 |
| 0.5 | NAb | NA | 7.0 (3.9) | 16 (94) | NA | NA |
| 6 | 7.5 (6.4) | 12 (92) | 13.2 (10.8) | 16 (94) | 10.8 (9.5) | .01 |
| 24 | 3.1 (1.9) | 13 (100) | 6.9 (4.2) | 16 (94) | 5.2 (3.8) | .01 |
| 48 | 3.0 (2.0) | 12 (92) | 5.0 (2.0) | 14 (82) | 4.1 (2.2) | .02 |
Abbreviations: ARCADIAN, Assessment and Review of Cognition, Alzheimer Disease, and Inflammation in Elderly Patients After Hospital Intervention; CAPACITY, Cerebrospinal Fluid and Preclinical Alzheimer Cognitive Trajectory; NA, not applicable.
a
P values compare the 2 study groups.
b
By design, blood samples were not taken 30 minutes after surgical incision in the CAPACITY study.