Table 2.

Summary of small molecules targeting Mcms.

Name	Classification	Targeting mechanism	References
Genistein	Isoflavone	Downregulation of Mcm2	Majid et al., 2010
Trichostatin A	HDAC inhibitor	Downregulation of Mcm2 (through the activation of JNK signaling pathway)	Majid et al., 2010; Liu et al., 2013
Widdrol	Aromatic compund	Downregulation of Mcm2-7 (through the activation of RB by DNA damage)	Hong et al., 2009; Kwon et al., 2010; Yun et al., 2012
Lovastatin	HMG-CoA reductase inhibitor	Downreguation of Mcm2 (through the activation of JNK signaling pathway)	Zhang X. et al., 2015
Metformin	Biguanide	Downregulation of Mcm2-7	Kim et al., 2017
BETi	Molecular mimicker of acetylated histone	Downregulation of Mcm5	Mio et al., 2016
Breviscapine	Flavonoid	Downregulation of Mcm7	Guan et al., 2017
Heliquinomycin	Antibiotic compound	Inhibition of Mcm4/6/7 helicase	Ishimi et al., 2009; Toyokawa et al., 2011
Ciprofloxacin	Fluoroquinolone	Inhibition of Mcm2-7 and Mcm4/6/7 helicase	Simon et al., 2013