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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Trends Pharmacol Sci. 2018 Feb 23;39(4):424–436. doi: 10.1016/j.tips.2018.02.001

Figure 4. The chemical structure of the different classes of smCD38i.

Figure 4

The overall mechanism of action is the inhibition of NAD breakdown. To date no inhibitors can selectively block the glycohydrolase vs the cyclase activity of CD38. NAD analogs can be considered covalent and non-covalent inhibitors. Ara-NAD analogs are covalent competitive inhibitors. Carba-analogs are non-covalent competitive inhibitors. Most flavonoids and small molecule inhibitors of CD38 are non-covalent competitive inhibitors. RHein is the only uncompetitive inhibitor in the flavonoid class.