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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1–137.
Recommended Regimens for Adults*

Early Latent Syphilis
Benzathine penicillin G 2.4 million units IM in a single dose
Late Latent Syphilis or Latent Syphilis of Unknown Duration
Benzathine penicillin G 7.2 million units total, administered as 3 doses of 2.4 million units IM each at 1-week intervals

*Recommendations for treating syphilis in persons with HIV infection and pregnant women are discussed elsewhere in this report (see Syphilis in Persons with HIV infection and Syphilis during Pregnancy).