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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1–137.
Recommended Intramuscular/Oral Regimens
Ceftriaxone 250 mg IM in a single dose
 PLUS
Doxycycline 100 mg orally twice a day for 14 days
 WITH* or WITHOUT
Metronidazole 500 mg orally twice a day for 14 days
 OR
Cefoxitin 2 g IM in a single dose and Probenecid, 1 g orally administered concurrently in a single dose
 PLUS
Doxycycline 100 mg orally twice a day for 14 days
 WITH or WITHOUT
Metronidazole 500 mg orally twice a day for 14 days
 OR
Other parenteral third-generation cephalosporin (e.g., ceftizoxime or cefotaxime)
 PLUS
Doxycycline 100 mg orally twice a day for 14 days
 WITH* or WITHOUT
Metronidazole 500 mg orally twice a day for 14 days
*The recommended third-generation cephalsporins are limited in the coverage of anaerobes. Therefore, until it is known that extended anaerobic coverage is not important for treatment of acute PID, the addition of metronidazole to treatment regimens with third-generation cephalosporins should be considered (Source: Walker CK, Wiesenfeld HC. Antibiotic therapy for acute pelvic inflammatory disease: the 2006 CDC Sexually Transmitted Diseases Treatment Guidelines. Clin Infect Dis 2007;28[Supp 1]:S29–36).