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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1–137.
Recommended Regimens

For acute epididymitis most likely caused by sexually transmitted chlamydia and gonorrhea
Ceftriaxone 250 mg IM in a single dose
 PLUS
Doxycycline 100 mg orally twice a day for 10 days
For acute epididymitis most likely caused by sexually-transmitted chlamydia and gonorrhea and enteric organisms (men who practice insertive anal sex)
Ceftriaxone 250 mg IM in a single dose
 PLUS
Levofloxacin 500 mg orally once a day for 10 days
 OR
Ofloxacin 300 mg orally twice a day for 10 days
For acute epididymitis most likely caused by enteric organisms
Levofloxacin 500 mg orally once daily for 10 days
 OR
Ofloxacin 300 mg orally twice a day for 10 days