Recommended Regimens for External Anogenital Warts (i.e., penis, groin, scrotum, vulva, perineum, external anus, and perianus*)

Patient-Applied:

Imiquimod 3.75% or 5% cream†

OR

Podofilox 0.5% solution or gel

OR

Sinecatechins 15% ointment†

Provider–Administered:

Cryotherapy with liquid nitrogen or cryoprobe

OR

Surgical removal either by tangential scissor excision, tangential shave excision, curettage, laser, or electrosurgery

OR

Trichloroacetic acid (TCA) or bichloroacetic acid (BCA) 80%–90% solution

*Many persons with external anal warts also have intra-anal warts. Thus, persons with external anal warts might benefit from an inspection of the anal canal by digital examination, standard anoscopy, or high-resolution anoscopy.

†Might weaken condoms and vaginal diaphragms.