. 2018 Apr 4;14:125. doi: 10.1186/s12917-018-1441-0

Table 2.

Mucosal S100A12 and MPO levels in relation to histopathologic changes in the colon and cecum

Histopathological findings	n	Severity groups	S100A12 (μg/L) Median (IQR)	P value^a	MPO (ΔA/min) Median (IQR)	P value^a
Colon	15
Total histopathological severity	15	Insignificant (n = 7)	49.01 (10.8-184.68)	0.0274 ^b	1.04 (0.22-3.37)	0.1280
		Mild (n = 7)	111.4 (32.81-538.8)		1.49 (0.38-4.08)
		Moderate (n = 1)	1296.65		6.61
Morphological criteria	15
Epithelial injury	15	Normal (n = 8)	44.18 (10.8-184.68)	0.0083 ^b	1.28 (0.22-4.08)	0.4232
		Mild (n = 3)	254.57 (89.16-536.8)		1.49 (0.57-2.59)
		Moderate (n = 3)	111.4 (32.81-211.53)		0.68 (0.38-3.01)
		Severe (n = 1)	1296.65		6.61
Crypt hyperplasia	15	Normal (n = 11)	89.61 (10.8-536.8)	0.8412	1.1 (0.22-3.37)	0.3437
		Mild (n = 3)	33.53 (32.81-1296.65)		1.46 (0.68-6.61)
		Moderate (n = 1)	44.9		4.08
Crypt dilation and distorsion	15	Normal (n = 12)	76.01 (10.8-536.8)	0.5706	1.48 (0.22-4.08)	0.5858
Crypt dilation and distorsion	15	Mild (n = 3)	49.01 (32.81-1296.65)	0.5706	1.1 (0.68-6.61)	0.5858
Mucosal fibrosis and atrophy	15	Normal (n = 8)	53.97 (10.8-1296.65)	0.4267	0.86 (0.22-6.61)	0.9124
		Mild (n = 5)	111.4 (43.45-254.57)		2.59 (0.38-3.37)
		Moderate (n = 1)	536.8		1.49
		Severe (n = 1)	33.53		1.46
Inflammatory criteria	15
Lamina propria LPC	15	Normal (n = 2)	312.98 (89.16-536.8)	0.0554	1.03 (0.57-1.49)	0.4088
		Mild (n = 9)	49.01 (22.89-211.53)		1.1 (0.22-3.37)
		Moderate (n = 3)	44.9 (10.8-254.57)		2.59 (0.28-4.08)
		Severe (n = 1)	1296.65		6.61
Lamina propria eosinophils	15	Normal (n = 9)	63.04 (10.8-254.57)	0.1076	1.04 (0.22-3.37)	0.1516
		Mild (n = 3)	33.53 (22.89-89.16)		1.46 (0.57-2.04)
		Moderate (n = 3)	536.8 (44.9-1296.65)		4.08 (1.49-6.61)
Lamina propria neutrophils	15	Normal (n = 10)	46.96 (10.8-1296.65)	0.2448	1.07 (0.22-6.61)	0.9400
		Mild (n = 4)	161.47 (33.53-254.57)		2.02 (0.38-3.01)
		Moderate (n = 1)	536.8		1.49
Lamina propria macrophage	15	Normal (n = 15)	63.04 (10.8-1296.65)	–	1.46 (0.22-6.61)	–
Cecum	6
Total histopathological severity	6	Insignificant (n = 6)	160.38 (8.62-405.48)	–	0.68 (0.12-1.66)	–
Morphological criteria	6
Epithelial injury	6	Normal (n = 3)	34.02 (8.62-249.74)	0.2187	0.37 (0.12-1.66)	0.4642
Epithelial injury	6	Mild (n = 3)	351.79 (71.02-405.48)	0.2187	0.97 (0.4-1.51)	0.4642
Crypt hypeplasia	6	Normal (n = 5)	71.02 (8.62-351.79)	0.3225	0.97 (0.12-1.66)	0.7163
Crypt hypeplasia	6	Mild (n = 1)	405.48	0.3225	0.4	0.7163
Crypt dilation and distorsion	6	Normal (n = 5)	249.74 (8.62-405.48)	0.5229	0.98 (0.37-1.66)	0.0715
Crypt dilation and distorsion	6	Mild (n = 1)	34.02	0.5229	0.12	0.0715
Mucosal fibrosis and atrophy	6	Normal (n = 6)	160.38 (8.62-405.48)	–	0.68 (0.12-1.66)	–
Inflammatory criteria	6
Lamina propria LPC	6	Normal (n = 2)	211.41 (71.02-351.79)	0.6222	1.24 (0.97-1.51)	0.2594
Lamina propria LPC	6	Mild (n = 4)	141.88 (8.62-405.48)	0.6222	0.38 (0.12-1.66)	0.2594
Lamina propria eosinophils	6	Normal (n = 3)	34.02 (8.62-249.74)	0.2181	0.37 (0.12-1.66)	0.4642
Lamina propria eosinophils	6	Mild (n = 3)	351.79 (71.02-405.48)	0.2181	0.97 (0.4-1.51)	0.4642
Lamina propria neutrophils	6	Normal (n = 5)	71.02 (8.62-405.48)	0.4075	0.68 (0.12-1.66)	0.3664
Lamina propria neutrophils	6	Moderate (n = 1)	351.79	0.4075	1.51	0.3664
Lamina propria macrophage	6	Normal (n = 6)	160.38 (8.62-405.48)	–	0.68 (0.12-1.66)	–

Association between mucosal S100A12 concentrations and MPO activities with severity of histopathological findings in the colon and cecum of dogs with CE. Statistical differences were calculated based on the log-transformed values of S100A12 and MPO. Untransformed values are reported as median (IQR)

n sample size, IQR interquartile range, LPC lymphocytes/plasma cells

^aANOVA test after logarithmic transformation of original values

^bstatistically significant association