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SIRT3 deficiency aggravates HFD-induced cognitive dysfunction. (a) Representative immunoblots of mitochondria and cytosol SIRT3 were detected by Western blots. WT and SIRT3 KO mice with or without HFD were subjected to 6-week AIT. (b) Escape latency of place navigation test. (c) Staying time in the quadrant in space probe test. ∗P < 0.05 versus WT; #P < 0.05 versus HFD. Values are means ± SEM, n = 6 independent experiments.
