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. 2018 Apr 5;18:385. doi: 10.1186/s12885-018-4315-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of the work flow of this study. Previous studies resulted in the discovery and validation of a multi-gene signature. In this study, gene expression data were used to correlate the selected gene CTSK with clinical and histopathological parameters. From the same cohort of tumor samples, a TMA was constructed for immunohistochemical analysis of the selected gene to correlate their protein expression with clinical and histopathological parameters, and outcomes were compared