Table 4.
Univariate and multivariate DSS Cox regression model for gene and protein CTSK expression
| Univariate | |||
|---|---|---|---|
| HR | 95% CI | p-value | |
| Agea | 1.01 | 0.48–2.12 | 0.978 |
| Tumor stageb | 4.01 | 1.21–13.29 | 0.023 |
| pNc | 4.10 | 1.66–10.15 | 0.002 |
| CTSK protein expression (stroma) | 2.40 | 1.05–5.50 | 0.038 |
| CSTK protein expression (tumor) | 2.79 | 1.02–7.64 | 0.045 |
| CTSK gene expression | 2.29 | 1.01–5.21 | 0.047 |
| Multivariate | |||
| pN status | 3.61 | 1.12–11.57 | 0.030 |
| corrected for CTSK protein expression (tumor) | |||
Dichotomization was made according to the cut-off values into high and low expression. The most important prognostic parameters (age, stage and pN) were added in the regression model
a< 60 vs. ≥60 years; bI, II vs. III, IV; c pN0 vs. pN+