Table 3.

Reactome network analysis revealing significant association with mitotic regulation

Associated Pathway	Genes	FDR
mitotic pro metaphase	CCNB1, CKAP5, BUB1, CENPF, CENPE, NDC80	FDR ≤ 3.33 x 10-4
mitotic metaphase and anaphase	CKAP5, LMNA, BUB1, CENPF, CENPE, NDC80, UBE2C, PSME1	FDR ≤ 1.00 x 10-3
mitotic G2-G2/M phase	CCNB1, CKAP5, NEK2, CENPF, AURKA	FDR ≤ 1.00 x 10-3
APC/C-mediated degradation of cell cycle proteins	AURKA, UBE2C, CCNB1, PSME1	FDR ≤ 4.80 x 10-3

Reactome network analysis revealed pathways associated with mitotic regulation. These networks predominantly involve spindle assembly checkpoint, centromere-kinetochore complex and cell cycle regulation