Table 2.
GWAS disease-TCM gene pairs with q < 0.2 identified from this study.
| TCM name | Diseases (Z-score) |
|---|---|
| 1β-Hydroxyalantolactone | Ovarian cysts (3.952), ovarian diseases (3.365) |
| Ainsliadimer A | Neoplasms, glandular and epithelial (4.051) |
| Artemisinin | Diabetes mellitus, type 1 (4.526) |
| Benzoylaconitine | Embolism and thrombosis (5.058) |
| Benzyl benzoate | Embolism and thrombosis (6.157) |
| Berberine hydrochloride | Central nervous system infections (4.626) hemorrhage (5.090), hypertension, pregnancy-induced (4.347), prion diseases (5.433) |
| Borneol | Embolism and thrombosis (4.754) |
| Britanin | Central nervous system infections (5.323), prion diseases (4.554) |
| Bruceine D | Intestinal diseases (3.126), lip diseases (4.480), lymphoproliferative disorders (3.190), mouth abnormalities (4.471), skin diseases, papulosquamous (4.167) |
| Bufalin | Lip diseases (12.748), mouth abnormalities (12.730), skin diseases, papulosquamous (6.010), spinal diseases (5.987) |
| Chelerythrine | Autoimmune diseases of the nervous system (3.526) |
| Cholic acid | Embolism and thrombosis (4.536) |
| Cinnamaldehyde | Embolism and thrombosis (4.559) |
| Cinnamic acid | Embolism and thrombosis (5.398) |
| Curculigoside | Hypersensitivity, immediate (3.676) |
| Daidzin | Autoimmune diseases of the nervous system (4.358), bone marrow diseases (5.015), demyelinating autoimmune diseases, cns (3.744) |
| Deoxycholic acid | Embolism and thrombosis (5.072) |
| Four mixture | Autoimmune diseases of the nervous system (3.198), breast diseases (4.159), breast neoplasms (4.137), demyelinating autoimmune diseases, cns (3.263), gastrointestinal neoplasms (3.648), lymphoproliferative disorders (4.073), neoplasms, glandular and epithelial (3.244) |
| Gamabufatalin | Gastroenteritis (4.344), skin diseases, papulosquamous (5.028) |
| Gentiopicroside | Breast diseases (4.249), breast neoplasms (4.251) |
| Ginsenoside Rb2 | Embolism and thrombosis (4.604) |
| Ginsenoside Rb3 | Embolism and thrombosis (5.758) |
| Ginsenoside Rc | Embolism and thrombosis (6.291) |
| Ginsenoside Rd | Embolism and thrombosis (5.214) |
| Ginsenoside Re | Embolism and thrombosis (5.722) |
| Ginsenoside Rg1 | Skin diseases, papulosquamous (4.279) |
| Isoborneol | Embolism and thrombosis (4.441) |
| Japonicone A | Acneiform eruptions (3.354), arthritis, rheumatoid (3.591), breast diseases (4.482), breast neoplasms (4.473), central nervous system infections (4.303), cocaine-related disorders (3.625), digestive system neoplasms (3.370), gastrointestinal neoplasms (5.216), intestinal diseases (3.592), leukemia (3.687), lymphoma (4.369), lymphoproliferative disorders (4.066), neoplasms, glandular and epithelial (3.772), ovarian diseases (3.535), prion diseases (5.863), rheumatic diseases (3.599), sebaceous gland diseases (3.357), urinary bladder diseases (3.722), urologic neoplasms (3.506) |
| Liquiritin | Autoimmune diseases of the nervous system (3.704), glucose metabolism disorders (4.245), hypersensitivity, immediate (3.993) |
| Narciclasine | Bone marrow diseases (3.974), gastroenteritis (3.703), intestinal diseases (3.734), lymphoma (3.848), lymphoproliferative disorders (4.190), osteitis deformans (3.623), peripheral vascular diseases (3.707), prion diseases (4.772), skin diseases, papulosquamous (4.086) |
| Nitidine chloride | Arthritis (3.319), bone marrow diseases (3.701), breast diseases (5.287), breast neoplasms (5.259), diabetes mellitus, type 2 (5.288), digestive system neoplasms (3.605), gastrointestinal neoplasms (3.712), glucose metabolism disorders (5.115), intestinal diseases (3.572), lymphoproliferative disorders (3.936), neoplasms, glandular and epithelial (4.427) |
| Notoginsenoside R1 | Ovarian cysts (4.713), ovarian diseases (4.526) |
| Oleanic acid | Breast diseases (3.698), breast neoplasms (3.681), digestive system neoplasms (3.838), gastrointestinal neoplasms (4.394), muscular diseases (4.916), myositis (4.915), neoplasms (5.028) |
| Osthole | Neoplasms (5.137) |
| Salidroside | Autoimmune diseases of the nervous system (3.615), hypersensitivity, immediate (3.817), neoplasms (4.994) |
| Sanguinarine | Breast diseases (4.521), breast neoplasms (4.535) |
| Santonin | Breast neoplasms (3.506), gastrointestinal neoplasms (3.576) |
| Schisantherin A | Hypersensitivity, immediate (3.660) |
| Tanshinone IIA | Body weight (3.665), central nervous system infections (4.831), prion diseases (5.608) |
| Tetrahydropalmatine | Autoimmune diseases of the nervous system (4.315), demyelinating autoimmune diseases, cns (3.999), hypersensitivity, immediate (3.792) |