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. 2018 Mar 22;2018:7642158. doi: 10.1155/2018/7642158

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Copyright © 2018 Anhuan Shi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Histological features of the penumbra in cerebral I/R rats (H&E staining): (a) sham group; (b) vehicle group; (c) 30 mg/kg Nimodipine group; (d) 40 mg/kg PCGE group; (e) 4 mg/kg PCGE group. Bar = 20 μm. In the sham group, the cortex showed many normal neurons (arrowheads) and astrocytic nuclei (arrows). In the vehicle group, ischemic penumbra showed shrunken, dense, and angular neurons (arrowheads) and swollen astrocytic nuclei (arrows). Nimodipine or PCGE treatment reduced the pathological lesions in the penumbra of cerebral I/R rats.