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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: Bioessays. 2018 Jan 23;40(3):10.1002/bies.201700176. doi: 10.1002/bies.201700176

Figure 1.

Figure 1

Mapping and regulation of the Ndc80-Ska interactions (A). Schematic drawing of the domains of Ska subunits and Ndc80. The solid line with arrows shows the verified interactions. The dashed lines with arrows show the speculative interactions. The Ska-Ndc80 interactions, including both the verified and speculative ones, are subject to Aurora B regulation in a cell cycle-dependent manner. At prophase/prometaphase, the Ska complex and the Ndc80 complex are spatially close to Aurora B and thereby readily phosphorylated. Aurora B phosphorylations of Ska and Ndc80 might inhibit the Ndc80-Ska interactions, thus preventing Ska kinetochore accumulation. At metaphase, the Ska and Ndc80 complexes are dephosphorylated, leading to a full Ska accumulation at kinetochores. B) Summary of the functions of Ska domains.