Table 2. Summary Estimates of Percentages of Participants With All-Grade or High-Grade Cardiovascular Adverse Events by Type of Event.
| Outcome | All-Grade Adverse Events | Grade ≥3 Adverse Events | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. of Studies | % (95% CI) | P Value | I2 |
I2 P Value |
No. of Studies | % (95% CI) | P Value | I2 |
I2 P Value |
|
| All events | 22 | 18.1 (13.5-23.3) |
<.001 | 87.4 | <.001 | 24 | 8.2 (5.9-10.7) |
<.001 | 71.6 | <.001 |
| Congestive heart failure | 17 | 4.1 (2.3-6.2) |
<.001 | 65.2 | <.001 | 23 | 2.5 (1.5-3.8) |
<.001 | 49.2 | .004 |
| Hypertension | 16 | 12.2 (9.8-14.9) |
<.001 | 54.1 | .004 | 17 | 4.3 (2.6-6.4) |
<.001 | 60.3 | .001 |
| Arrhythmia | 13 | 2.4 (0.4-5.6) |
.004 | 84.4 | <.001 | 17 | 0.8 (0.3-1.4) |
<.001 | 0 | .86 |
| Ischemia | 13 | 1.8 (0.8-3.0) |
<.001 | 38.0 | .08 | 18 | 0.8 (0.4-1.4) |
<.001 | 0 | .78 |
| Cardiac arrest | NA | NA | NA | NA | 24 | 0.0 (0.0-0.1) |
>.99 | 0 | .98 | |
| Dyspnea | 17 | 23.9 (18.4-29.9) |
<.001 | 88.4 | <.001 | 18 | 3.2 (2.2-4.3) |
<.001 | 29.5 | .11 |
| Edema | 12 | 24.7 (21.0-28.6) |
<.001 | 64.2 | .001 | 12 | 0.4 (0.1-0.9) |
<.001 | 0 | .61 |
Abbreviation: NA, not applicable.