Figure 5. Network Plots for Intraventricular Hemorrhage and Oliguria.

These 2 outcome measures for treatment of hemodynamically significant patent ductus arteriosus were evaluated in the Bayesian network meta-analysis. Each node indicates a treatment modality and is sized proportionally to the number of infants who received the treatment modality. Each line connecting 2 nodes indicates a direct comparison between 2 modalities, and the thickness of each is proportional to the number of trials directly comparing the 2 modalities. Seldom-used variations of indomethacin were condensed into a single node termed indomethacin, other types. A standard dose of ibuprofen is 10 mg/kg followed by 5 mg/kg every 12 to 24 hours for a total of 3 doses. A high dose of ibuprofen is 15 to 20 mg/kg followed by 7.5 to 10 mg/kg every 12 to 24 hours for a total of 3 doses. IV indicates intravenous.