Table. Associations of Long-Chain Acylcarnitines With Left Ventricular Structure and Function.
| Characteristics | Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|
| Multivariablea | Fullb | |||||
| β (95% CI) | P Value | β (95% CI) | P Value | β (95% CI) | P Value | |
| Left ventricular mass index | ||||||
| C16 | 18.04 (6.47 to 29.62) | .003 | 18.17 (5.33 to 31.01) | .007 | 19.24 (5.48 to 33.01) | .008 |
| C18:1 | 24.52 (14.21 to 34.84) | <1.0 × 10-4 | 25.44 (14.16 to 36.72) | <1.0 × 10-4 | 26.18 (14.04 to 38.32) | 1.0 × 10-4 |
| C18:2 | 16.78 (4.90 to 28.66) | .007 | 17.09 (4.21 to 29.96) | .01 | 17.42 (3.40 to 31.43) | .02 |
| C18 | 20.66 (9.52 to 31.80) | 6.0 × 10-4 | 17.14 (7.58 to 26.70) | 9.0 × 10-4 | 25.25 (10.91 to 39.58) | .001 |
| C26 | 15.44 (3.41 to 27.47) | .01 | 18.04 (3.76 to 32.32) | .0147 | 19.93 (4.41 to 35.45) | .01 |
| Left ventricular ejection fraction | ||||||
| Choline | −7.29 (−12.11 to 2.47) | .004 | −6.39 (−12.38 to 0.40) | .04 | −4.50 (−10.46 to 1.45) | .13 |
| Kynurenine | −7.99 (−12.70 to 3.27) | .001 | −7.94 (−14.61 to 1.28) | .02 | −3.31 (−11.42 to 4.79) | .41 |
| C18:2 | −6.88 (−11.76 to 2.00) | .007 | −6.97 (−11.95 to −1.99) | .007 | −6.11 (−10.88 to −1.34) | .01 |
| Relative wall thickness | ||||||
| C26 | 0.05 (0.01 to 0.09) | .01 | 0.04 (−0.01 to 0.08) | .11 | NAc | NAc |
Abbreviation: NA, not applicable.
a
Adjusted for age, sex, diabetes status, and estimated glomerular filtration rate.
b
Further adjustment includes B-type natriuretic peptide.
c
Since C26 did not associate significantly after partial statistical analysis, additional adjustment and testing was inappropriate.