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. 2018 Jan 31;3(3):14–22. doi: 10.1001/jamacardio.2017.5205

Figure 2. Associations of Omega-3 Fatty Acids With Subtypes of Coronary Heart Disease and Major Vascular Events, by Trial.

Figure 2.

Symbols and conventions as in Figure 1. Study names are AREDS-2, Age-Related Eye Disease Study 2; DOIT, Diet and Omega-3 Intervention Trial; GISSI-HF, Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure; GISSI-P, Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Prevenzione; JELIS, Japan Eicosapentaenoic Acid (EPA) Lipid Intervention Study; OMEGA, Effect of Omega 3-Fatty Acids on the Reduction of Sudden Cardiac Death After Myocardial Infarction; ORIGIN, Outcome Reduction With Initial Glargine Intervention; SU.FOL.OM3, Supplémentation en Folates et Omega-3; R&P, Risk and Prevention Study. Rate ratios for individual trials or subgroups of trials are indicated by squares and the 99% CIs by the horizontal lines. Overall totals and their 95% confidence intervals are represented by diamonds. Arrowheads indicate error bars that extend beyond the area shown. Heterogeneity between all trials (χ29 in all cases) for nonfatal myocardial infarction, coronary heart disease death, any coronary heart disease, and major vascular events were 10.18 (P = .34), 12.3 (P = .20), 12.92 (P = .17), and 7.68 (P = .57), respectively.