Table 3.
a. Genetic Variants Associated with Carotid IMT in European Americans (p < 1.0E-4) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Chr. | SNP | Position, bpa | Gene/Nearest Gene | Loc. | A1b | MAFc | BETA | SE | Pf |
15 | rs1867148 | 73127038 | PPCDC | I | C | 0.44 | −0.2804 | 0.06064 | 5.11E-06 |
13 | rs323453 | 104232379 | LOC728183/DAOA | IG | G | 0.34 | −0.2724 | 0.06346 | 2.23E-05 |
1 | rs4846566 | 217797888 | LOC728510/ZC3H11B | IG | T | 0.01 | −1.186 | 0.2777 | 2.46E-05 |
2 | rs12987042 | 38518674 | ARL6IP2/RPLPO-like | IG | A | 0.36 | −0.2608 | 0.0619 | 3.13E-05 |
15 | rs6495122 | 72912698 | CPLX3/ULK3 | IG | A | 0.42 | −0.2525 | 0.06149 | 4.90E-05 |
1 | rs2645091 | 2214505 | SKI | I | T | 0.15 | −0.3511 | 0.08741 | 7.07E-05 |
16 | rs17821532 | 52504199 | FTO | I | A | 0.05 | −0.7006 | 0.1751 | 7.58E-05 |
6 | rs7742814 | 119185974 | C6orf204/ASF1A | IG | G | 0.36 | 0.2555 | 0.06462 | 9.09E-05 |
11 | rs4387380 | 5824023 | OR52E6/OR52E8 | IG | C | 0.03 | −0.8226 | 0.2085 | 9.45E-05 |
b. Genetic Variants Associated with Plaque in European Americans (p < 1.0E-4) | |||||||||
---|---|---|---|---|---|---|---|---|---|
Chr. | SNP | Position, bpa | Gene/Nearest Gene | Loc | A1b | MAFc | ORd | 95% CIe | Pf |
12 | rs515291 | 38689259 | SLC2A13 | I | G | 0.32 | 0.4987 | 0.36–0.69 | 3.09E-05 |
11 | rs10501399 | 68979039 | MYEOV/CCND1 | IG | T | 0.09 | 0.2938 | 0.16–0.52 | 3.34E-05 |
15 | rs692390 | 39274282 | EXDL1 | I | A | 0.19 | 0.4138 | 0.27–0.63 | 4.30E-05 |
5 | rs6887230 | 148706339 | GRPEL2 | I | G | 0.30 | 2.02 | 1.4–2.8 | 5.61E-05 |
17 | rs2070776 | 59361230 | CD79B | C (ns) | T | 0.33 | 0.5033 | 0.36–0.71 | 6.68E-05 |
16 | rs3785233 | 7607511 | A2BP1 | I | C | 0.16 | 0.419 | 0.27–0.65 | 9.49E-05 |
6 | rs10948573 | 50800310 | TFAP2D | I | G | 0.37 | 2.044 | 1.4–2.9 | 9.68E-05 |
Chr. = chromosome; SNP = single nucleotide polymorphism;
Based on NCBI Build36/130 (hg18); Loc = Location; I = Intron; IG = Intergenic;
A1 = minor allele;
MAF = minor allele frequency;
OR = Odds Ratio;
CI = Confidence Interval;
p values ranked from low to high.