Table 4.
Chr. | SNP | Location, bpa | Gene/Nearest Gene | Type | Mexican Americans | European Americans | Combined p valuec | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A1b | MAF | β-SNP (SE) | p-value | A1b | MA F | β-SNP (SE) | p-value | ||||||
15 | chr15:73071294 | 73071294 | RPP25/SCAMP5 | IG | A | 0.02 | −0.5279 (0.1834) |
0.004133 | A | 0.02 | −0.7115 (0.2012) |
4.54×10−4 | 2.66×10−5 |
11 | rs582037 | 125723080 | DCPS/ST3GAL4 | IG | A | 0.40 | 0.1308 (0.0386) |
0.005611 | A | 0.33 | 0.234 (0.0648) |
3.48×10−4 | 2.76 × 10−5 |
3 | rs4839634 | 144619509 | SLC9A9 | I | G | 0.15 | 0.1592 (0.0633) |
0.01215 | G | 0.14 | 0.3274 (0.0897) |
2.96×10−4 | 4.87 × 10−5 |
Plaque | OR (SE) | OR (SE) | |||||||||||
1 | rs6694848 | 63276194 | LOC199897/FOXD3 | IG | A | 0.33 | 1.516 (0.1309) |
0.001473 | A | 0.46 | 1.782 (0.1718) |
7.69×10−4 | 1.66×10−5 |
3 | rs9809344 | 135825448 | KY | I | T | 0.23 | 0.7201 (0.1428) |
0.02147 | T | 0.39 | 0.5426 (0.1676) |
2.64×10−4 | 7.41×10−5 |
13 | rs7327080 | 22689882 | SGCG | I | G | 0.33 | 1.404 (0.1259) |
0.007004 | G | 0.32 | 0.5607 (0.1774) |
0.001111 | 9.93×10−5 |
Chr. = chromosome; SNP = single nucleotide polymorphism; MAF = minor allele frequency;
Based on National Center for Biotechnology Information (NCBI) Build36 (hg18);
A1 = minor allele;
combined p values ranked from low to high;