Table 3.
Comparison of cervicovaginal fluid cytokine concentrations (pg/ml) in relation to delivery outcome.
| Outcome | IL-1α | IL-1β | IL-2 | IL-6 | IL-8 | IL-10 | IL-12 | RANTES | TNF-α | IFN-γ |
|---|---|---|---|---|---|---|---|---|---|---|
| GTP1 (20–22 weeks) | ||||||||||
| Term (n = 25) | 1167 (375.6–4053) | 773.8 (285.6–2351) | 24.4 (16.8–29.0) | 13.6 (4.9–42.4) | 9771 (3437–15864) | 6.5 (5.3–9.0) | 10.3 (4.7–13.7) | 9.2 (6.2–12.9) | 6.6 (4.6–8.3) | 15.9 (4.2–19.6) |
| Preterm (n = 22) | 812.9 (216.5–1521) | 590.8 (132.6–1121) | 23.1 (18.3–26.2) | 9.9 (5.6–22.3) | 6873 (386.4–14548) | 6.2 (5.7–8.4) | 10.2 (4.9–12.1) | 6.7 (4.8–10.6) | 6.4 (4.8–7.5) | 14.9 (4.3–18.9) |
| P-value | 0.22 | 0.40 | 0.54 | 0.46 | 0.42 | 0.93 | 0.50 | 0.22 | 0.47 | 0.63 |
| GTP2 (26–28 weeks) | ||||||||||
| Term (n = 33) | 661.3 (270.3–1576) | 566.4 (59.3–1438) | 0.0 (0.0–6.1) | 7.3 (0.0–22.4) | 6979 (2596–13990) | 0.0 (0.0–1.4) | 1.6 (0.0–2.1) | 3.4 (1.9–7.8) | 0.0 (0.0–1.3) | 0.0 (0.0–0.0) |
| Preterm (n = 17) | 888.3 (549.8–2579) | 659 (310.6–1152) | 0.0 (0.0–6.3) | 15.6 (2.9–290.5) | 10225 (4815–15493) | 0.0 (0.0–1.3) | 0.0 (0.0–2.0) | 4.8 (1.1–8.2) | 0.0 (0.0–1.3) | 0.0 (0.0–0.0) |
| P-value | 0.24 | 0.43 | 0.47 | 0.09 | 0.39 | 0.71 | 0.08 | 0.81 | 0.94 | NA |
| GTP1/GTP2 ratio | ||||||||||
| Term | 1.59 (0.2–2.9) | 3.1 (0.3–14.9) | 4.0 (2.8–4.8) | 2.2 (0.4–5.4) | 1.0 (0.1–3.4) | 4.0 (2.9–7.3) | 4.7 (2.6–6.1) | 2.2 (1.7–4.6) | 5.8 (3.0–6.2) | 4.8 (4.8–4.8) |
| (n = 18) | (n = 17) | (n = 17) | (n = 9) | (n = 11) | (n = 17) | (n = 9) | (n = 12) | (n = 13) | (n = 7) | (n = 1) |
| Preterm | 0.6 (0.01–1.5) | 0.6 (0.1–1.9) | 4.0 (1.8–9.3) | 0.6 (0.03–3.38) | 0.3 (0.04–1.4) | 5.6 (4.2–4474) | 3.6 (2.4–5.7) | 1.3 (0.5–1.5) | 4.7 (2.5–5.5) | 6.5 (6.5–6.5) |
| (n = 16) | (n = 16) | (n = 16) | (n = 8) | (n = 15) | (n = 16) | (n = 5) | (n = 5) | (n = 13) | (n = 5) | (n = 1) |
| P-value | 0.25 | 0.04* | 0.96 | 0.09 | 0.14 | 0.19 | 0.65 | 0.004** | 0.34 | NA |
GTP, gestational time point; NA, not applicable. Data presented as median (25th and 75th percentiles). GTP1/GTP2 ratios were computed for only those women who provided paired samples i.e. women sampled at both gestational time points. The total n = 34 (Term = 18 & Preterm = 16) are those women who were sampled at both GTPs. Samples without a particular cytokine or cytokine concentration below the detectable limit of the assay kit (indicated as a value of zero) were subsequently omitted when computing ratios.