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. 2017 Dec 1;32(4):874–881. doi: 10.1038/leu.2017.313

Figure 3.

Figure 3

Example of a patient with an MPAL. The leukemic cells (in red) are dim CD45+/CyCD3-/SmCD3-/partially CyMPO+/partially CD34+/partially CD19+/partially CyCD79a+. The database-guided analysis showed a main pointer to Myeloid (34%) and B (52%), indeed suggesting an MPAL. The overall immunophenotype was partially CD34+/partially CD117+/weak HLADR+/weak CD45+/CD13+/CD33+/CD11b-/CD14-/CD15-/CD16-/CD36-/CD64-/CD56-/partially TdT+/heterogeneous CD123+/CD66c+/CyIgM-/partially CD10+/IgM-/partially CD22+/CD20-. Morphology showed 90% blasts, Sudan black positive in 5% of cells. Cytogenetics showed 46,XX,t(9;22)(q34;q11), BCR-ABL1-positive. According to WHO2008 the patient was diagnosed as MPAL (myeloid/B) with t(9;22). Normal T-cells (dark blue), NK cells (middle blue), mature B-cells (green), eosinophils (light blue), granulocytes (purple), monocytes (orange) and immature erythroid cells (brown) are shown as well.