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. 2017 Nov 28;27(3):463–474. doi: 10.1093/hmg/ddx415

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© The Author(s) 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — No significant loss of spinal cord motor neurons in hFUS (+/+) mice at post-natal day 15 and day 21. (A) Cresyl violet staining of the large diameter α-motor neurons in the ventral horn of the lumbar spinal cord in NTg, hFUS (+/−) and hFUS (+/+) mice at P15, P21 and P56. (B) At P15, there was no significant difference in the number of motor neurons between NTg, hFUS (+/−) and hFUS (+/+) mice and hence no neuronal loss in hFUS (+/+) mice despite NMJ degeneration. At P21, there was a non-significant reduction in the number of motor neurons in all three genotypes compared with P15 [NTg P = 0.78, hFUS (+/−) P = 0.08, hFUS (+/+) P = 0.10], which reached significance by P56 [NTg P = 0.009, hFUS (+/−) P = 0.002, hFUS (+/+) P < 0.001]. In hFUS (+/+) mice there was a significant loss of motor neurons compared with NTg and hFUS (+/−) mice at the end-stage P56 [NTg vs hFUS (+/+) P < 0.001, hFUS (+/−) vs hFUS (+/+) P = 0.004]. (N = 3–4 for all genotypes). Significance was determined using a 2-way ANOVA with a Holm-Sidak post hoc test.

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