Figure 8.

Early mitochondrial abnormalities at the pre-synaptic nerve terminals in a small number of neuromuscular junctions in hFUS (+/+) mice at post-natal day 6. Mitochondrial abnormalities were found at the axon terminals of the hFUS (+/+) mice in a small proportion of NMJs without apparent loss of synaptic vesicles. Mitochondria were lost (B) or reduced in density, appeared darker in colour (C), with disorganised cristae (A) and ‘onion-ring’ membranes (D). M, mitochondrion; V, synaptic vesicles; NT, nerve terminal; J, junctional folds; N, nucleus; SC, Schwann cell (scale bar: 500 nm).