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. 2017 Jul 19;26(19):3850–3858. doi: 10.1093/hmg/ddx285

Table 2.

Regions with strong evidence of pleiotropy. For each region the number of SNPs, start and stop position in basepairs (bp) and most strongly associated SNPs for OA and BMD are given. Chromosome coordinates are in hg19. Hypothesis 3 = one causal variant; hypothesis 4 = two distinct causal variants; PP = posterior probability

Analysis SNPs Chr Start (bp) Stop (bp) Top SNP BMD Top SNP OA PP
Hypothesis 3 combinedOA and LSBMD 817 chr14 91297823 93129850 rs1286147; rs1286063 rs1286077 0.95
hipOA and FNBMD 817 chr14 91297823 93129850 rs1286147 rs1286077 0.98
hipOA and LSBMD 817 chr14 91297823 93129850 rs1286147; rs1286063 rs1286077 0.99
hipOA and LSBMD 1242 chr10 78708452 80875213 rs7071206 rs716255 0.92
hipOA and LSBMD 531 chr1 44974119 46897698 rs7554123 rs7545984 0.91
kneeOA and FNBMD 1235 chr6 19208477 21677746 rs9466056 rs9466056 0.99
Hypothesis 4 hipOA and LSBMD 268 chr4 696848 1415698 rs3755955 rs3755920 0.97
kneeOA and LSBMD 382 chr16 14464538 16152940 rs4985155 rs9935327 0.95
kneeOA and LSBMD 1070 chr6 150255029 151910904 rs4869742 rs9384514 0.90