Table 2.
Regions with strong evidence of pleiotropy. For each region the number of SNPs, start and stop position in basepairs (bp) and most strongly associated SNPs for OA and BMD are given. Chromosome coordinates are in hg19. Hypothesis 3 = one causal variant; hypothesis 4 = two distinct causal variants; PP = posterior probability
| Analysis | SNPs | Chr | Start (bp) | Stop (bp) | Top SNP BMD | Top SNP OA | PP | |
|---|---|---|---|---|---|---|---|---|
| Hypothesis 3 | combinedOA and LSBMD | 817 | chr14 | 91297823 | 93129850 | rs1286147; rs1286063 | rs1286077 | 0.95 |
| hipOA and FNBMD | 817 | chr14 | 91297823 | 93129850 | rs1286147 | rs1286077 | 0.98 | |
| hipOA and LSBMD | 817 | chr14 | 91297823 | 93129850 | rs1286147; rs1286063 | rs1286077 | 0.99 | |
| hipOA and LSBMD | 1242 | chr10 | 78708452 | 80875213 | rs7071206 | rs716255 | 0.92 | |
| hipOA and LSBMD | 531 | chr1 | 44974119 | 46897698 | rs7554123 | rs7545984 | 0.91 | |
| kneeOA and FNBMD | 1235 | chr6 | 19208477 | 21677746 | rs9466056 | rs9466056 | 0.99 | |
| Hypothesis 4 | hipOA and LSBMD | 268 | chr4 | 696848 | 1415698 | rs3755955 | rs3755920 | 0.97 |
| kneeOA and LSBMD | 382 | chr16 | 14464538 | 16152940 | rs4985155 | rs9935327 | 0.95 | |
| kneeOA and LSBMD | 1070 | chr6 | 150255029 | 151910904 | rs4869742 | rs9384514 | 0.90 |