Table 1.
Characteristics of the discovery and replication cohorts and per COPD status
| Discovery cohort |
Replication cohort |
|||||
|---|---|---|---|---|---|---|
| COPD | Controls | All | COPD | Controls | All | |
| N (% of all) | 114 (15.7)a | 541 (74.7) | 724 | 93 (12.1)a | 591 (77.2) | 766 |
| Age (years)a | 61.9±8.6 | 59.3±7.9 | 59.9±8.2 | 68.2±5.7 | 67.6±5.9 | 67.7±5.9 |
| Males (%) | 68 (59.6) | 233 (43.1) | 331 (45.7) | 54 (58.1) | 249 (42.1) | 324 (42.3) |
| FEV1/FVC(% of all) | 0.63±0.07(71.9) | 0.78±0.04(66.0) | 0.76±0.08(67.0) | 0.63±0.07(95.7) | 0.79±0.05(91.0) | 0.76±0.08(91.8) |
| Current smokers, n (%)a | 43 (37.7) | 107 (19.8) | 168 (23.2) | 20 (21.5) | 52 (8.8) | 80 (10.4) |
| Ex-smokers, n (%) | 55 (48.2) | 239 (44.2) | 322 (44.5) | 51 (54.8) | 326 (55.2) | 427 (55.7) |
| Never smokers, n (%) | 16 (14.0) | 195 (36.0) | 234 (32.3) | 22 (23.7) | 213 (36.0) | 259 (33.8) |
| Pack-yearsb | 34.3±26.9 | 19.9±19.6 | 23.2±22.0 | 33.7±18.7 | 19.6±20.1 | 21.9±20.6 |
Data for quantitative measures presented as mean ± SD. COPD: Chronic Obstructive Pulmonary Disease cases; All: all participants included in EWAS. For traits that were not available for all participants (COPD status and FEV1/FVC), the valid percentage is denoted in brackets (% of all).
a
Significantly different between the discovery and replication cohort.
b
Pack-years data were available for all participants (mean and SD calculated in current and ex-smokers only).