Table 3. Multivariable Cox proportional hazards regression model used to develop MDACC ICI Prognostic Score.

Parameter	HR (95% CI)	P-value
Age>52 years	1.6 (1.1, 2.4)	0.0290
ECOG>1	2.8 (1.3, 6.3)	0.0110
LDH>0.75 × ULN	2.1 (1.4, 3.2)	0.0003
Platelet>300	1.8 (1.2,2.8)	0.0064
ANC>4.9	2.3 (1.6, 3.5)	0.0005
ALC<1.8	3.3 (1.9, 5.7)	0.0004
Liver metastases	1.8 (1.2, 2.6)	0.0020

Abbreviations: ALC=absolute lymphocyte count; ANC=absolute neutrophil count; CI=confidence interval; ECOG PS=Eastern Cooperative Group performance status; HR=hazard ratio; LDH=lactate dehydrogenase; MDACC ICI=MD Anderson Cancer Center Immune Checkpoint Inhibitor; ULN=upper limit of normal.

Seven clinical variables associated with significantly worse overall survival were incorporated into the MDA ICI prognostic score.

HRs are based on the retrospective analysis.