Figure 1.
Kaplan–Meier estimates of OSRT, PFS and LC calculated from the beginning of radiotherapy. Overall survival (OSRT), progression-free survival (PFS) and local tumour control of the irradiated area (LC) were calculated from start of the first radiotherapy. The patient cohort with concomitant BRAF inhibitor and radiotherapy (RT w BRAFi) was compared to the cohort with radiotherapy and interrupted BRAF inhibitor (RT w/o BRAFi). OSRT, PFS and LC were calculated for concomitant and interrupted BRAF inhibitor treatment during radiotherapy (A, B, C) and for the subgroups treated with vemurafenib and dabrafenib (D, E, F). BRAFi=BRAF inhibitor; RT=radiotherapy.