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. 2017 Apr 25;26(14):2701–2718. doi: 10.1093/hmg/ddx158

Figure 9.

Figure 9

Autophagic dysfunction in mcoln1ab−/− hair cells at 5 dpf. (A,B) Higher magnification of TEM showing autophagic vacuoles containing electro-dense inclusions, organelles and other cytoplasmic contents in mcoln1ab−/− hair cells. (C) Typical lamellar structure in mcoln1ab−/− hair cells. (D,E) Typical lamellar structures in MLIV fibroblasts. (F) Electron-transparent matrix and reduced cristae in mcoln1ab−/− hair cell mitochondria. (G,H) Autolysosomes containing partially degraded mitochondria inside in mcoln1ab−/− hair cells. Scale bar for (A) and (B), 200 nm. Scale bar for (C) to (H), 80 nm.