Table 1.
Top up and down regulated mRNA targets in DD cells when compared to WT cells that showed inverse correlation with their respective miRNAs
| Gene | Description | Pathway | log2 fold change | P-value |
|---|---|---|---|---|
| Down regulated | ||||
| SGK1 | Serum and glucocorticoid-regulated kinase 1 | HD signaling | −2.73 | 1.47E-68 |
| TGM2 | Tissue transglutaminase 2 | HD signaling | −2.28 | 2.66E-75 |
| ITGA5 | Integrin alpha-5 | Apoptosis | −2.16 | 3.43E-09 |
| CPLX2 | Complexin-2 | HD signaling | −1.94 | 6.17E-36 |
| SYK | Spleen tyrosine kinase | Inflammation | −1.87 | 8.50E-36 |
| PRKCA | Protein kinase C alpha type | Apoptosis | −1.76 | 5.36E-157 |
| GRIP1 | Glutamate receptor-interacting protein 1 | Glutamate receptor signaling | −1.71 | 3.12E-48 |
| GRIN1 | Glutamate receptor ionotropic, NMDA 1 | Dopamine/cAMP signaling; Glutamate receptor signaling | −1.56 | 4.00E-03 |
| CAPN6 | Calpain-6 | Apoptosis | −1.54 | 4.05E-05 |
| KCNJ3 | G protein-activated inward rectifier potassium channel 1 | Dopamine/cAMP signaling | −1.44 | 1.83E-02 |
| GRM2 | Metabotropic glutamate receptor 2 | Glutamate receptor signaling | −1.31 | 3.19E-02 |
| CACNA1C | Voltage-dependent L-type calcium channel subunit alpha-1C | Dopamine/cAMP signaling | −1.01 | 4.08E-04 |
| GRM7 | Metabotropic glutamate receptor 7 | Glutamate receptor signaling | −0.89 | 1.18E-11 |
| Up regulated | ||||
| SLC18A1/ VMAT1 | Solute carrier 18A1/vesicular monoamine transporter 1 | Dopamine receptor signalling | 1.66 | 1.75E-229 |
| MAP3K5/ ASK1 | Mitogen-activated protein kinase kinase kinase 5/Apoptosis signal-regulating kinase 1 | Apoptosis | 1.16 | 4.64E-20 |
| CYGB | Cytoglobin | Superoxide radical degradation | 1.04 | 1.29E-29 |
| MYCN | N-myc proto-oncogene protein | ERK/MAPK signaling | 0.94 | 7.32E-10 |
| HSPA1A | Heat shock 70 kDa protein 1A | HD signaling | 0.76 | 7.59E-08 |
| CCND1 | Cyclin-D1 | cell cycle control (PI3/Akt) | 0.63 | 5.77E-42 |
| MAPK11 | Mitogen-activated protein kinase 11 | PD signaling | 0.63 | 9.45E-11 |
| SLC1A1 | Solute carrier 1A1/Excitatory amino acid transporter 3 | Glutamate receptor signaling | 0.61 | 1.78E-05 |
| THEM4 | Acyl-coenzyme A thioesterase | Cell cycle control (PI3/Akt) | 0.55 | 1.92E-06 |
| BMPR1B | Bone morphogenetic protein receptor type-1B | PTEN signaling | 0.48 | 3.92E-09 |
| Hsc70 | Heat shock 70 kDa protein 8/Heat shock cognate 71 kDa protein | HD signaling | 0.46 | 3.27E-16 |
| DRD2 | Dopamine receptor D2 | Dopamine receptor signalling; Dopamine/cAMP signaling | 0.45 | 7.31E-04 |
| KCNJ8 | ATP-sensitive inward rectifier potassium channel 8 | Dopamine/cAMP signaling | 0.44 | 7.68E-07 |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | HD signaling | 0.43 | 1.26E-07 |
| RPS24 | 40S ribosomal protein S24 | PD signaling | 0.38 | 6.27E-03 |
| IFT57 | Intraflagellar transport protein 57 homolog | HD signaling | 0.38 | 6.99E-07 |