Figure 5.

Tibial nerve fibers show demyelination in nmd mice. (A) (Left panel) Representative sample of wild-type tibial nerve fibers indicating location of Schwann cell nucleus (star) and nodes of Ranvier (arrows). (Right panel) High magnification images showing wild-type axons with normal myelin, node of Ranvier (arrows), and Schwann cell nucleus (star). (B) (Left panel) Representative sample of nmd tibial nerve teased fibers showing a bundle of axons completely demyelinated (lightning bolt), axons with myelin fragmentation (triangle) and axons with normal myelin and nodes of Ranvier (arrows). Note that in demyelinated axons and fragmented myelin axons, no nodes of Ranvier can be identified. (Left panel) High magnification images of axons with fragmented myelin.