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. 2017 Aug 30;26(23):4541–4555. doi: 10.1093/hmg/ddx333

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Evaluation of mitochondrial depolarization in human PBMCs obtained from carriers of rs11237379 gene variant associated with decreased NDUFC2 expression. (A–D) Cytofluorimetric assay for mitochondrial membrane potential (Δψm) at baseline and under stimulation with LPS or high-salt medium. The Δψm values among the unstimulated PBMCs obtained from homozygous (TT) and heterozygous (TC) carriers for the rs11237379 and PBMCs from carriers of wild-type genotype (CC) were similar (A and C; one-way ANOVA with Dunnett's test: ^P = NS versus PBMCs from CC genotype). After high-salt or LPS stimulation only PBMCs from TT and TC genotypes showed significant Δψm reductions with respect to baseline levels (B and D; one-way ANOVA with Dunnett's test: *P < 0.05 versus PBMCs from healthy controls).