Figure 7.
Renal secretion in B6- and MRL-Atp6v1b1vtxmutant mice at 17 weeks of age. (A) Urine alkalinity is significantly increased in vtx mice compared to wildtype controls in the B6 background, but not in the MRL background. Urine pH of MRL+/+ mice is significantly higher than that of B6+/+ mice and similar to that of vtx/vtx mutant mice on either strain background. (B) Calcium excretion is decreased in the mutant mice for both genetic backgrounds, but with a much larger decrease in MRL. Values are expressed as mean ± SE and each group contained 5 male mice. The Student’s paired t-test with two-tailed distribution was used to determine the statistical probabilities shown in A and B.