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. 2017 Sep 13;26(24):4765–4777. doi: 10.1093/hmg/ddx350

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Crosstalk between DPR proteins: GA sequesters GP. (A) HEK-293 cells were transfected with (GA-EGFP+EGFP, GA-EGFP+GP-EGFP, GA-EGFP+GR-EGFP, GA-EGFP+PA-EGFP and GA-EGFP+PR-EGFP). Cells were immunostained with specific rabbit antibodies against DPRs (GA, GP, GR, PA and PR; red). Green indicates EGFP-expressing DPRs and blue shows nuclear counterstaining with DAPI. Scale bar = 5 μm. (B) Human brain sections (temporal lobe) from C9orf72 expansion carriers were used for double-staining with poly GA (green) against poly GP (red) (n=3). (C) The percentage of poly GA and poly GP positive cells show that the majority of poly GP aggregates are positive with poly GA on hippocampal neuron (***P<0.0001).