Skip to main content
. 2017 Oct 12;27(1):30–40. doi: 10.1093/hmg/ddx381

Figure 1.

Figure 1.

Cognitive behavior in 12-month-old tau and non-transgenic wild-type (WT) mice. (A) Rotarod test in 12-month-old tau mice (n = 15) and non-transgenic WT mice (n = 15). (B) Latency to find platform test in 12-month-old tau and non-transgenic WT mice. (C) Swimming speed in 12-month-old tau and non-transgenic WT mice. (D) Time spent target quadrant in 12-month-old tau and non-transgenic WT mice. Rotarod: significantly reduced latency to fall on an accelerating rotarod test was found in 12-month-old tau mice (P=0.001) relative non-transgenic WT mice (A) and the latency to fall in all four trails was consistent in tau mice, suggesting that impairments in motor learning and coordination was progressive. Morris Water Maze test: an increase in escape latency to find the hidden platform during training between trials 7 and 16 relative to WT mice and the average latency time to find platform was significantly increased in tau mice (P=0.0001) compared with WT mice (B). Swimming speed. Tau mice displayed a gradually decreased swimming speed relative to WT mice and an average swimming speed was significantly decreased in tau mice (P=0.0001) compared with WT mice (C). Tau mice spent reduced time in all 16 trials on target quadrant compared with WT mice and average time spent in target quadrant was significantly decreased in tau mice (P=0.0001) compared with WT mice (D).