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. 2017 Nov 8;27(2):283–294. doi: 10.1093/hmg/ddx399

Figure 4.

Figure 4.

Alteration of BBSome proteins in the absence of BBS8. (A) Immunoblot showing levels of indicated BBS proteins in retinal extracts from Bbs8 null animals (−/−) prior to photoreceptor degeneration at P10. Littermate controls, both heterozygous and wild-type are shown for comparison. GAPDH serves as a loading control. (B) Similar to Panel A, immunoblot showing the levels of indicated BBS proteins in retinal extracts from P18 animals lacking BBS8. (C) Quantitation of BBS proteins shown in panel A (n = 3) normalized to GAPDH levels at P10. *P <  0.05; *** P <  0.0001 as determined by t-test.