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Summary of findings for all variants from computational predictions, functional testing of mutants alone, and functional testing of mutant and WT interactions. Testing of mutants alone suggested no enrichment for deleterious variants in IGD compared with controls. However, Mutant + WT co-transfections revealed that IGD-associated variants were more likely to be deleterious, (i.e. LoF in 2 or 3 assays), than Control variants (*P = 0.0270). Red= deleterious, Gray= Benign.
