Figure 2.

Direct comparison of ConDel predictions with results of functional testing. ConDel predictions were largely aligned with the results of functional testing for each mutant, except for mutants that caused LoF in only 1 signaling pathway. For those mutants, some were predicted to be neutral and others deleterious, and these were evenly split as to whether they were IGD-associated or seen only in Controls. Mutants that were LoF in 2–3 assays were more likely predicted to be deleterious by ConDel (^#P < 0.0001), and more commonly associated with IGD (*P < 0.0006), while mutants that tested benign were more mostly predicted to be neutral, regardless of whether they were associated with IGD or seen in Controls (n.s.).