. 2017 Sep 19;26(24):4836–4848. doi: 10.1093/hmg/ddx362

Table 4.

Genotypes recovered from crosses of Copb2 alleles

*Copb2^Zfn*
	Copb2^wt/wt	Copb2^Zfn/wt	Copb2^Zfn/Zfn**
E11.5 - E18.5	13	22	0 (8.75)
E7.5 - E10.5	3	8	0 (2.75)

*Copb2^null*

	Copb2^wt/wt	Copb2^null/wt	Copb2^null/null*
E12.5	7	11	0 (4.5)

*Copb2^R254C*

	Copb2^wt/wt	Copb2^R254C/wt	Copb2^R254C/R254C
weaning	41	57	34 (33)

*Copb2 ^R254C/Zfn*

	control	Copb2^R254C/Zfn*
P0	70	15 (21.25)
P1	60	11 (18)

Copb2^Zfn, Copb2^null, Copb2^R254Cdata are from matings of heterozygous mice. Copb2 ^R254C/Zfndata are from matings of Copb2^Zfn and Copb2^R254Cmice. Expected numbers of mutant animals are indicated by parentheses.

Statistical significance of the reductions in mutant numbers was determined with a chi-squared analysis (**P ≤ 0.01; *P ≤ 0.05).