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UBTF E210K is associated with cell-cycle defects and apoptosis in human fibroblasts. (A) Representative fibroblast cell-cycle histograms from normal control and UBTF E210K patient. (B) Percentage of cells present in G1, S and G2 phases. Values are expressed as means ± SEM. *P < 0.05 (n = 4–7/genotype). (C) Representative photomicrographs show TUNEL labeling of fibroblasts from a normal control and UBTF E210K patient. Scale bar, 100 µm.
